Journal articles

 

 

Lemke U, Krones-Herzig A, Berriel Diaz M, Ziegler A, Metzger D, Vegiopoulos A, Kirilov M, Maier J, Cato A, Screaton RA, Müller-Decker K, Kersten S, Herzig S. Control of hepatic dyslipidemia through a glucocorticoid receptor – Hes1 repressor metabolic axis. Cell Metabolism  In press

 

48. Stienstra R, Duval C, Keshtkar S, van der Laak J, Kersten S, Müller M. (2008) PPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue. J. Biol. Chem. Jun 9. [Epub ahead of print]

 

47. Joosten, MM, Beulens JWJ, Kersten S, Hendriks HFJ. (2008) Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia  May 27 [Epub ahead of print]

 

46. Sanderson LM, de Groot PJ, Koppen A, Kalkhoven E, Hooiveld GJEJ, Müller M, Kersten S. (2008) Effect of Synthetic Dietary Triglycerides: a Novel Research Paradigm for Nutrigenomics. PlosONE 3: e1681.

 

45. Joosen AM, Kersten S, Bakker AK, Westerterp K. (2008) The PPARg ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARg in the subcutaneous adipose tissue. Br. J. Nutr. 99:487-93.

 

44. Kersten S. (2008) PPARs and lipoprotein metabolism. PPAR research. 2008:132960.

 

43. Wieneke N, Hirsch-Ernst KI, Kuna M, Kersten S, Püschel GP. (2007) PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation. FEBS Lett. 581:5617-26.

 

42. Lichtenstein L, Berbee JFP, van Dijk SJ, Willems van Dijk K, Bensadoun A, Kema, IP,Voshol PJ, Müller M, Rensen PCN, Kersten S. (2007) Angptl4 upregulates cholesterol synthesis in liver by inhibiting LPL- and HL-dependent remnant uptake. Arterioscler. Thromb. Vasc. Biol. 27:2420-7

 

41. Rakhshandehroo M, Sanderson L, Zhu W, de Groot P, Müller M, Kersten S. (2007) Global analysis of gene expression by PPARα in liver: Identification of triglyceride hydrolysis as novel PPARα dependent pathway. PPAR research. 2007:26839.

 

40. Bunger M, Hooiveld GJ, Kersten S, Muller M. (2007) Exploration of PPAR functions by microarray technology-A paradigm for nutrigenomics. Biochim. Biophys. Acta. 1771:1046-64.

 

39. Duval C, Müller M, Kersten S. (2007) PPARs and dyslipidemia. Biochim. Biophys. Acta. 1771:961-71.

 

38. Bünger M, van den Bosch H, van der Meijde J, Kersten S, Hooiveld G, Müller M. (2007) Genome-wide analysis of PPARa activation in murine small intestine. Physiol. Genom. 30:192-204.

 

37. Mandard S, Stienstra R, Escher P, Tan NS, Kim I, Gonzalez FJ, Wahli W, Desvergne B, Müller M, Kersten S. (2007) Glycogen Synthase 2 is a novel target gene of Peroxisome Proliferator-Activated Receptors. Cell. Mol. Life Sci. 64:1145-57.

 

36. Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Müller M. (2007) PPARα protects against obesity-induced hepatic inflammation. Endocrinology. 148:2753-63.

 

35. Busstra C, Hartog R, Kersten S, Müller M. (2007) Design guidelines for the development of digital nutrigenomics learning material for heterogeneous target groups. Advances in Physiology Education 31:67-75.

 

34. Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C, Morgan ET, Lichtenauer-Kaligis E, Kersten S, Müller M. (2007) The Interleukin 1 receptor antagonist is a direct target gene of PPARa in liver. J. Hepatol. 46:869-77.

 

33. Stienstra R, Duval C. Müller M, Kersten S. (2007) PPARs, obesity and inflammation. PPAR research. 2007:95974.

 

32. Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede R, Meyer UA, Rucker C (2006)

Sulfonylureas and Glinides Exhibit PPARgamma Activity: A Combined Virtual Screening and Biological Assay Approach. Mol. Pharmacol. 71:398-406.

 

31. Knauf C, Rieusset J, Foretz M, Cani PD, Uldry M, Hosokawa M, Martinez E, Bringart M, Waget A, Kersten S, Desvergne B, Gremlich S, Wahli W, Seydoux J, Delzenne NM, Thorens B, Burcelin R. (2006) Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology. 147:4067-78.

 

30. Zandbergen F, van Dijk S, Muller M, Kersten S. (2006) Fasting-induced adipose factor/Angiopoietin-like protein 4: a potential target for dyslipidemia. Future Lipidology. 1:227-236.

 

29. Patsouris D, Reddy JK, Muller M, Kersten S. (2006) PPARalpha mediates the effects of high fat diet on hepatic gene expression. Endocrinology. 147:1508-16.

 

28. Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Müller M, and Kersten S. (2006) The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem.  281:934-44.

 

27. Joosen AM, Bakker AH, Zorenc AH, Kersten S, Schrauwen P, Westerterp KR. (2006) PPARgamma activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding. Int. J. Obes. (Lond). 30:302-7.

 

26. Kersten S. (2005) Regulation of lipid metabolism via angiopoietin-like proteins. Biochem. Soc. Trans. 33:1059-62.

 

25. Zandbergen FJ, Escher P, Mandard S, Tan NS, Patsouris D, van der Meijde J, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri, S, Müller M, and Kersten S. (2005) The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J. 392:313-24.

 

24. Hermann LM, Pinkerton M, Jennings K, Yang L, Grom A, Sowders D, Kersten S, Witte DP, Hirsch R, Thornton S. (2005) Angiopoietin-like-4 is a potential angiogenic mediator in arthritis. Clin Immunol. 115:93-101.

 

23. Genolet R, Kersten S, Braissant O, Mandard S, Tan NS, Bucher P, Desvergne B, Michalik L, Wahli W. (2005) Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 280:24143-52.

 

22. Patsouris D, Muller M, Kersten S. (2004) Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance. Curr. Opin. Investig. Drugs. 5:1045-50.

 

21. Mandard S, Zandbergen F, Tan NS, Escher P, Patsouris D, Koenig W, Kleemann R, Bakker A, Veenman F, Wahli W, Müller M, Kersten S. (2004) The direct PPAR target FIAF/PGAR/ANGPTL4 is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J. Biol. Chem. 279:34411-20.

 

20. Patsouris D, Mandard S, Voshol PJ, Escher P, Tan NS, Havekes LM, Koenig W, März W, Tafuri S, Wahli W, Müller M,  Kersten S. (2004) The Peroxisome Proliferator Activated Receptor alpha governs glycerol metabolism. J. Clin. Invest. 114:94-103.

 

19. IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B. (2004) In vivo activation of PPAR target genes by RXR homodimers. EMBO J. 23:2083-91.

 

18. Mandard M, Müller M, Kersten S. (2004) Peroxisome proliferator activated receptor a target genes. Cell. Mol. Life Sci. 61:393-416.

 

17. Müller M, Kersten S. (2003) Nutrigenomics: goals and strategies. Nat. Rev. Genet. 4:315-22.

 

16. Kersten S. (2002) Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c. Proc. Nutr. Soc. 61:371-4.

 

15. Kersten S. (2002) Peroxisome Proliferator Activated Receptors and obesity. Eur. J. Pharmacol.  440:223-34.

 

14. Kersten S, Mandard S, Escher P, Gonzalez FJ, Tafuri S, Desvergne BD, and Wahli W. (2001) The peroxisome proliferator activated receptor alpha regulates amino acid metabolism. FASEB J. 15:1971-1978.

 

13. Kersten S. (2001) Nutritional and hormonal regulation of lipogenesis. EMBO rep. 2:282-286.

 

12. Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, and Wahli W. (2000) Characterization of the fasting induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 275:28488-28493.

 

11. Kersten S, Desvergne BD, and Wahli W. (2000) Roles of PPARs in health and disease. Nature 405:421-424.

 

10. Di Croce L, Okret S, Kersten S, Gustafsson JA, Parker M, Wahli W, Beato M. (1999) Steroid and nuclear receptors. villefranche-sur-mer, france, may 25-27, 1999. EMBO J. 18:6201-10.

 

9. Kersten S, Seydoux, J, Peters JM, Gonzalez FJ, Desvergne B, and Wahli W. (1999) Peroxisome proliferator activated receptor alpha mediates the adaptive response to fasting.  J. Clin. Invest. 103: 1489-1498.

 

8. Kersten S, Dong D, Lee WY, Reczek PR, Noy N. (1998) Auto-silencing by the retinoid X receptor. J. Mol. Biol. 284: 21-32.

 

7. Kersten S, Reczek P, Noy N. (1997) The tetramerization domain of the retinoid X receptor is important for transcriptional activation by the receptor. J. Biol. Chem. 272: 29759-29768.

 

6. Kersten S, Gronemeyer H, Noy N. (1997) The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state. J.Biol. Chem. 272: 12771-12777.

 

5. Kersten S, Dawson MI, Lewis BA, Noy N. (1996) Individual subunits of heterodimers comprised of retinoic acid and retinoid X receptors interact with their ligands independently. Biochemistry 35: 3816-3824.

 

4. Rooyackers OE, Kersten AH, Wagenmakers AJ. (1996) Mitochondrial protein content and in vivo synthesis rates in skeletal muscle from critically ill rats. Clin. Sci. (Colch)  91: 475-481.

 

3. Kersten S, Pan L, Noy N. (1995) On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor. Biochemistry 34:14263-14269.

 

2. Kersten S, Pan L, Chambon P, Gronemeyer H, Noy N.  (1995) Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor. Biochemistry  4:13717-13721.

 

1. Kersten S, Kelleher D, Chambon P, Gronemeyer H, Noy N. (1995) Retinoid X receptor alpha forms tetramers in solution. Proc. Natl. Acad. Sci. U. S. A. 92: 8645-8649.